Association of single nucleotide polymorphisms in the LPA gene region with serum Lp(a) levels and myocardial infarction

Association of single nucleotide polymorphisms in the LPA gene region with serum Lp(a) levels and myocardial infarction Dissertation zur Erlangung des Doktorgrades der Naturwissenschaften (Dr. rer. Quidquid agis prudenter agas et respice finem. AA amino acid apo(a) apolipoprotein (a) asPCR allele-specific PCR BMI body mass index bp base pair CAD coronary artery disease CHD coronary heart disease CI confidence interval cM centiMorgan Da Dalton dbSNP public single nucleotide database EDTA Ethylendiamintetraacetate FAM 6-carboxyfluoresceine FBAT Family-Based Association Tests in genetic analyses GWA genome-wide association HDL high density lipoprotein HW Hardy-Weinberg KIV-2 kringle IV-like type 2 KV kringle V-like LD linkage disequilibrium LDL low density lipoprotein LOD logarithm of the odds MAF minor allele frequency MGB minor groove binder MI myocardial infarction NCBI National Center for Biotechnology Information OD optical density ON oligonucleotide, primer OR odds ratio PCR polymerase chain reaction QTL quantitative trait locus RefSeq reference sequence SD standard deviation SNP single (or: simple) nucleotide polymorphism Taq Thermus Aquaticus TDT Transmission Disequilibrium Test Tm melting temperature TRIS Tris(hydroxymethyl)aminomethane UCSC University of California Santa Cruz VIC a proprietary fluorescent dye produced by Applied Biosystems WHO World Health Organization